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Condyloma acuminatum (CA) is a disease caused by human papillomavirus (HPV) infection and characterized by anogenital proliferational lesions. The primary types of HPV responsible for this disease are 6 and 11. Many approaches are available for the treatment of CA. However, most of them only eradicate visible warts and improve symptoms and signs. As a result, the latent and subclinical infection of HPV persist, and recurrence frequently occurs. Hence, single local treatment is insufficient for CA. Development of effective strategies to kill HPV and enhance host immunity may be the stress of future research on CA treatment.