�������ľ�ҽ��ѧ����ҽԺƤ����

Th17ϸ����Ⱥ�ǽ��������ֵ�һ��CD4+Tϸ����Ⱥ�������׽���-17��6��22��������������-α��������������-γ�Ͱ׽���-4���ɽ鵼������֢��Ӧ�����������Լ�������������ֲ�ų�ȣ��ڻ������ߵ��ڡ����߲��������������Ӧ�з�����Ҫ���á��׽���-17��һ��ǿ��Ĵ������ӣ��ɷ�����Toll�����弤�������Ƶ����ü���������ߣ�ͬʱҲ����֢��Ӧ��΢�����ӣ��������ϸ�����Ӳ���Эͬ���ã��Ŵ�����ЧӦ���ٽ�������������Լ����ķ����ͷ�չ���о�������ϵͳ�Ժ���Ǵ�����м����ަ����ѿ�׼���Ӧ��Ƥ�׵Ȼ������Ѫ������ˮƽ�쳣����ʾTh17ϸ����Tϸ���鵼��Ƥ��������֢�����������Լ����йء�

Th17 cells are a new lineage of CD4+ effector T cells producing interleukin ��IL��-17, IL-6, IL-22 and TNF-αbut not IFN-γ or IL-4. Th17 cells can mediate chronic inflammatory reaction, autoimmune responses, tumor development, graft rejection and so on, and play an important role in immunoregulation, immunopathogenesis and host defense. IL-17 is not only a powerful proinflammatory factor that activates inherent immunity as Toll-like receptors do, but also a readjusting factor that cooperates with varied cytokines, amplifies inflammatory reaction, and in turn promotes the occurrence and development of various autoimmune disorders. It has been shown that there is an abnormality of serum factors in patients with SLE, psoriasis, mycosis fungoides or atopic dermatitis, indicating that Th17 cells are associated with T-cell mediated chronic cutaneous inflammation and autoimmune disorders.