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More and more evidences have shown that psoriasis is a chronic inflammation process mediated by immunity, including innate immunity and adaptive immunity. In the system of innate immunity, Toll-like receptors are the key receptors in protecting against microorganism intrusion. These receptors are expressed not only on peripheral blood cells, but also on epithelial cells in airway and immunocytes in epidermis, where pathogens may trigger the development or aggravate the activity of psoriasis. Therefore, regulating the expression of Toll-like receptors may affect the pathophysiology of many inflammatory diseases, such as psoriasis.