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Psoriasis is a disease of multifactorial inheritance, and not every member of offsprings of psoriasis patients would develop it. Epigenetics means inheritable changes in gene expression without any change in DNA sequence, and the expression of gene may be regulated via the following three mechanisms: DNA methylation, histone modification and noncoding RNA regulation (such as RNA interference). Genetic imprinting and inactivation of X chromosome are associated with epigenetic inheritance. Epigenetic changes have been found in tumors and some autoimmune diseases. The author reviews the advances in epigenetic changes in psoriasis, which may benefit the elucidation of psoriasis pathogenesis.