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��֢������ҩ�������֢���κ�ߡ�Stevens?۲Johnson �ۺ������ж��Ա�Ƥ�����ɽ�֢����Ƥ���������صļ���֮һ��������䷢�������߻������µ���ʶ����Ҫ����Fas?۲FasL�鵼��ϸ��������ϸ����Tϸ�������á�������������-α�յ�����������������˷��档���ٴ������п�Ӧ����������ҩ��羲����ע�����򵰰ס������ء�ɳ���Ȱ����������������ӵ���¡����ȡ�

Severe bullous drug eruption, including erythema multiforme major, Stevens-Johnson syndrome and toxic epidermal necrolysis, are one of the most severe skin diseases. Some advances have been made in their immunopathogenesis, such as the apoptosis mediated by Fas-FasL and induced by TNF-α, effect of cytotoxic T cells, and mitochondrial damage. Furthermore, these diseases can be managed with immunotherapy, e.g. intravenous immunoglobulin, cyclosporine, thalidomide and anti-TNF monoclonal antibodies.