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| PubMed | |
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Article by SU Yi-fan |
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Article by WANG Hua |
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�ɽ��ɫ����������ڵı�Ƥ���Ѷ������������������������Ƥ���ۺ�������Ƥ�����ѵ�ֱ��ԭ�ò����ٴ��������붾��Ѫ�������ء���Ƥ���Ѷ�����Ϊһ��˿���ᵰ��ø,�������ڱ�Ƥ������,�����Խ�ϲ�ˮ������о�ǵ���1,������о�ǵ���1�İ�����EC3��EC4֮�������Ȱ���381-X�ļ�,�Ӷ��γɱ�Ƥ�ڴ��塣����,��Ƥ���Ѷ��ػ�������Ϊ����ԭ���뷢����
Exfoliative toxins of Staphylococcus aureus and their mechanism of action in staphylococcal scalded skin syndrome
Department of Dermatology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China
Department of Dermatology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China
Exfoliative toxins(ETs) of Staphylococcus aureus are directly responsible for the skin exfoliation of staphylococcal scalded skin syndrome (SSSS). Clinical manifestations of SSSS are related to ETs serotypes. ETs act as serine proteases on the granular layer of epidermis, specifically bind to and hydrolyze desmoglein-1 by cleaving the Glu381-X peptide bond between the extracellular domain EC3 and EC4, so as to cause blisters within the epidermis. In addition, ETs may act as a superantigen in the pathogenesis of SSSS.
[2] Ladhani S,Joannou CL,Lochrie DP,et al.Clinical,microbial,and biochemical aspects of the exfoliative toxins causing staphylococcal scalded-skin syndrome.Clin Mierobiol Rev,1999,12(2):224-242.
[3] Plano LR.Staphylococcus aureus exfoliative toxins:how they cause disease.J Invest Dermatol,2004,122(5):1070-1077.
[4] Iwatsuki K,Yamasaki O,Morizane S,et al.Staphylococcal cutaneous infections:invasion,evasion and aggression.J Dermatol Sci,2006,42(3):203-214.
[5] Yamaguchi T,Nishifuji K,Sasaki M,ct al.Identification of the Staphylococcus aureus etd pathogenicity island which encodes a novel exfoliative toxin,ETD,and EDIN-B.Infect Immun,2002,70(10):5835-5845.
[6] Yamasaki O,Yamaguchi T,Sugai M,et al.Clinical manifestations of staphylococcal scalded-skin syndrome depend on serotypes of exfoliative toxins.J Clin Microbiol,2005,43(4):1890-1893.
[7] Vath GM,Earhart CA,Monie DD,et al.The crystal structure of exfoliative toxin B:a superantigen with enzymatic activity.Biochemistry,1999,38(32):10239-10246.
[8] Hanakawa Y,Schechter NM,Lin C,et al.Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome.J Clin Invest,2002,110(1):53-60.
[9] Cavarelli J,Prevost G,Bourguet W,et al.The structure of Staphylococcus aureus epidermolytic toxin A,an atypic serine protease,at 1.7 A resolution.Structure,1997,5(6):813-824.
[10] Nagasaka T,Nishifuji K,Ota T,et al.Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome.J Clin Invest,2004,114(10):1484-1492.
[11] Payne AS,Hanakawa Y,Amagai M,et al.Desmosomes and disease:pemphigus and bullous impetigo.Curr Opin Cell Biol,2004,16(5):536-543.
[12] Hanakawa Y,Stanley JR.Mechanisms of blister formation by staphylococcal toxins.J Biochem(Tokyo),2004,136(6):747-750.
[13] Amagai M.Desmoglein,the target molecule in autoimmunity and infection.Nihon Rinsho Meneki Gakkai Kaishi,2006,29(5):325-333.
[14] Hanakawa Y,Selwood T,Woo D,et al.Calcium-dependent conformgion of desmoglein 1 is required for its cleavage by exfoliative toxin.J Invest Dermatol,2003,121(2):383-389.
[15] Rago JV,Vath GM,Bohach GA,et al.Mutational analysis of the superantigen staphylococcal exfoliative toxin A(ETA).J Immunol,2000,164(4):2207-2213.