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��Ƥ��Բ�ѧ��־ 2007, 33(6) 337-339 DOI: ISSN: 2096-5540 CN: 32-1880/R

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	PubMed
	Article by KANG Ke-fei

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�в��һ�ֵ��Ե��,�ǹ��ѧ�о��Ҫ��󡣸��ȥ��Ǻ��ᡢ��ᡢ��ϵ�С�ϸ��Ӽ��Tϸ��о�,��ص��۲��в��ߵ��Ʒ��о��в��Ƥ��,��ʹ��Ƥ�ڲ��C3��ΪiC3b,,ͬʱ��һЩ��,Ѫ�е��ϸ��Ƥ�ͱ�Ƥ��Ǳ��CR3��iC3b��ÿ��ϵ��׽��-10,��µ��׽��-12,��һ��ԭ���׼�ø,�ر��Ƕ��ϸ��źŵ��ڼ�ø��ء�

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Investigation of the mechanisms of Ultraviolet B-induced immunosuppression

Shanghai Huashan Hospital, Shanghai 200040, China

Abstract:

Ultraviolet B (UVB) is the most biologically active ultraviolet reaching the earth��s surface, and is a main research target for photobiology. This review focuses on the mechanisms of UVB induced immunosuppression. The scope of the investigation is as follows:1)Deoxyribonucleic acid, 2)Urocanic acid, 3)Reactive oxygen species, 4)Cytokines and 5) Regulatory T cells. Very recently, the research is further extended to complement. After UVB irradiation upon skin, complement C3 in dermis developed into iC3b. Meanwhile, with effects of other factors, monocytes from blood migrate into dermis and epidermis. The complement receptor CR3 on the surface of these cells then interact with ligand iC3b followed by upregualtion of IL-10 expression and downregulation of IL-12 expression. This regulation is related to mitogen-activated protein kinase, especially to the upregulation of extracellular signal-regulated kinase.

Keywords: Ultraviolet rays Immunity Complement system proteins

�ո�� 2007-04-02 �޻�� ��淢��

DOI:

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