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Department of Dermatology, Changhai Hospital, Second Military Medical University, Shanghai 200433��China

With the increase in the number of HIV patients and organ transplantation, there has been a rise in the incidence of rare deep mycosis with high mortality and morbility. This review outlines the clinical manifestations and traditional therapies of rare deep mycosis, as well as recent advancements in antifungal therapy. Practical guidelines are presented for appropriate application of antifungal agents, including amphotericin B, fluconazole, itraconazole, etc