Advances in postoperative radiotherapy for keloids
Rong Li, Jia-An Zhang, Kun Chen*
Department of Physiotherapy, Hospital for Skin Disease (Institute of Dermatology), Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu 210042, China.
摘要 There is no standardized treatment strategy for keloid over present literatures. Radiotherapy combined with surgical resection was considered as one of the most effective treatment plans for keloid. In this paper, we here provide a comprehensive review over methods that radiotherapy applied in keloid in recent years. And several aspects including radiation types (X-ray radiation, electron beam radiotherapy and brachytherapy), radiation parameters, safety and effectiveness are also discussed in this article. Considering these factors, we hope if we could explore some new ideas for the optimal treatment of keloid.
Introduction
Keloids, a type of skin lesion that presents as pathologically excessive dermal fibrosis and aberrant wound healing, are caused by cell proliferation and hyaline degeneration of connective tissues. The specific pathogenesis of keloids is still unknown[1- 2]. There are multiple therapeutic strategies for keloids, including surgery, cryotherapy, laser or light-based therapy, and intralesional corticosteroid injection. However, none of these is optimal. Surgical excision combined with adjuvant radiation is considered to be a safer and more efficacious method[3]. From publicly available data, the recurrence rate of keloids after simple surgical excision amounts to 45% - 100%[4]. Based on published reports, postoperative adiotherapy results in a control rate of 67% - 81% , and the recurrence rate decreases to 24.5% - 35%[4-12]. This article reviews papers related to postoperative radiotherapy treatment for keloids, and also discusses radiation types, parameters, safety and effectiveness.
收稿日期: 2018-03-23
出版日期: 2019-01-15
基金资助:This work was supported by the National Natural Science Foundation of China (No.81872545 and No.81703152), and the CAMS Innovation Fund for Medical Sciences (No. CIFMS-2017-I2M-1-017).
通讯作者:
陈崑
E-mail: kunchen181@aliyun.com
引用本文:
李容 张家安 陈崑. Advances in postoperative radiotherapy for keloids[J]. 国际皮肤性病学杂志, 2018, 1(4): 212-216.
Rong Li, Jia-An Zhang, Kun Chen*. Advances in postoperative radiotherapy for keloids. International Journal of Dermatology and Venereolo, 2018, 1(4): 212-216.
2018, Vol. 1 
