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Clear cell squamous cell carcinoma (CCSCC) is a rare entity firstly described by Kuo in 1980[1]. The tumor cells are characterized by its clear appearance as the cell cytoplasm appears totally absent or eosinophilic transparent. CCSCC in situ is rarer as there are only 8 cases reported until now[2-3]. In 2007, Cohen et al.[2] reported 2 facial CCSCC in situ containing HPV in an octogenarian couple. At the same time, Al- Arashi et al.[3] discovered 6 CCSCC in situ in 1,500 con-secutive cases. In all reported cases, CCSCC and squamous cell carcinoma (SCC) with clear cell change seems to have similar clinical features and occur at the exposure site, as good as other types of SCC, mostly on the face, followed by thigh (male) and leg (female) with no difference in age and sex[2-3]. Here we reported a typical case of CCSCC occuring on the left cheek.

Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China.

Clear cell squamous cell carcinoma (CCSCC) is a rare entity firstly described by Kuo in 1980[1]. The tumor cells are characterized by its clear appearance as the cell cytoplasm appears totally absent or eosinophilic transparent. CCSCC in situ is rarer as there are only 8 cases reported until now[2-3]. In 2007, Cohen et al.[2] reported 2 facial CCSCC in situ containing HPV in an octogenarian couple. At the same time, Al- Arashi et al.[3] discovered 6 CCSCC in situ in 1,500 con-secutive cases. In all reported cases, CCSCC and squamous cell carcinoma (SCC) with clear cell change seems to have similar clinical features and occur at the exposure site, as good as other types of SCC, mostly on the face, followed by thigh (male) and leg (female) with no difference in age and sex[2-3]. Here we reported a typical case of CCSCC occuring on the left cheek.