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Vitiligo |
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Clinical feature |
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Familial case |
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Sporadic case |
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| PubMed | |
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Article by Liu,w |
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Article by Yang,m |
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Article by Gao,X.M |
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Article by Fu,y |
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Article by Pao,Y.Q |
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Article by Chang,J.M |
Differences of clinical features between familial and sporadic cases of vitiligo: a hospital-based study
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Objective To study the clinical differences between familial and sporadic cases of vitiligo. Methods Clinical data of 1,136 Chinese vitiligo patients in the Department of Dermatology in Beijing Hospital from January 2015 to December 2017 were obtained by questionnaire and statistically analyzed by SPSS 22.0 software. Results Among 1,136 patients enrolled, 233 cases (20.5%) had family history of vitiligo. The mean age at onset of vitiligo cases with family history was 24.45 ± 15.87 years old, and was significantly lower than that of sporadic cases, which was 28.12 ± 16.88 years old ( P < 0.05). The skin lesions distributed bilaterally in 71.3% of familial vitiligo cases and 60.8% of sporadic cases (P < 0.05), respectively. The difference on the clinical classification between the familial cases and sporadic cases was insignificant (P > 0.05). Conclusion Our study found that vitiligo patients with family history showed significant differences on the mean age at onset of disease and the distribution of skin lesions, which should be further studied in a wider population.
Differences of clinical features between familial and sporadic cases of vitiligo: a hospital-based study
Department of Dermatology, Beijing Hospital, National Center of Gerontology, Beijing 100005, China
Department of Dermatology, Beijing Hospital, National Center of Gerontology, Beijing 100005, China
Objective To study the clinical differences between familial and sporadic cases of vitiligo. Methods Clinical data of 1,136 Chinese vitiligo patients in the Department of Dermatology in Beijing Hospital from January 2015 to December 2017 were obtained by questionnaire and statistically analyzed by SPSS 22.0 software. Results Among 1,136 patients enrolled, 233 cases (20.5%) had family history of vitiligo. The mean age at onset of vitiligo cases with family history was 24.45 ± 15.87 years old, and was significantly lower than that of sporadic cases, which was 28.12 ± 16.88 years old ( P < 0.05). The skin lesions distributed bilaterally in 71.3% of familial vitiligo cases and 60.8% of sporadic cases (P < 0.05), respectively. The difference on the clinical classification between the familial cases and sporadic cases was insignificant (P > 0.05). Conclusion Our study found that vitiligo patients with family history showed significant differences on the mean age at onset of disease and the distribution of skin lesions, which should be further studied in a wider population.