Guangzhou Institute of Dermatology, Guangzhou, Guangdong 510095, China.

Introduction Epithelioid sarcoma (ES) is a rare, soft tissue sarcoma, which was first described by Enzinger in 1970[1]. It pre-dominantly arises in the extremities of young adults, and lymphatic spread is common, which is unlike other sarcomas. Immunohistochemistry has already been proven to be conclusive in supporting morpho-logical findings and in identifying histological sub-types. Co-expression of vimentin, cytokeratin (CK) and epithelial membrane antigen (EMA) are the immunohistochemical characteristics[2]. Here, we report a patient with negative staining of pan-CK, CK 5/6 and CK A1/A3.