1Department of Pharmacy, Lu′an People′s Hospital, Lu′an Affiliated Hospital of Anhui Medical University, Lu′an, Anhui 237005, China. 2Department of Dermatology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, China.

��Abstract�� Objective The aim of this study was to investigate the risk of non-Hodgkin lymphoma (NHL) in patients with psoriasis compared with the general population by meta-analysis. Methods Relevant articles characterizing the associated risk of NHL in patients with psoriasis were retrieved by searching the Cochrane Library, PubMed and Web of Science using the terms "no-Hodgkin lymphoma" and "lymphoma" combined with "psoriasis". The meta-analysis procedure was used to combine standardized incidence ratio with 95% confidence intervals (CIs) to evaluate the association. Data were extracted from each study and Version 12.0 STATA statistical software was used for analyses. Results Five cohort studies fulfilled the inclusion criteria and were subjected to the final analysis in the meta-analysis. The pooled SIR based on a fixed-effects model was 1.45, with a 95% CI of 1.29 to 1.63. No publication bias was detected. Conclusion Our meta-analysis demonstrated a positive association between NHL and psoriasis. Individuals with psoriasis have a heightened risk of developing NHL compared with the general population. The relationship between NHL and psoriasis requires further study using a larger sample size.