1Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, China. 2Department of Rheumatology and Immunology, Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, Yunnan, 650000, China.

��Abstract�� Objective To assess the association between angiotensin-converting enzyme��ACE�� gene polymorphisms and vitiligo risk. Methods Web of Science, PubMed, Embase, and Chinese databases including China National Knowledge Infrastructure (CNKI), Weipu, and Wanfang databases were used to identify articles which investigated the correlations between ACE gene polymorphism and vitiligo risk, and the reported genotype frequencies were analyzed using STATA software. Results Nine studies including 1,018 subjects in case group and 1,490 in control group were included in this work. Genotype distributions in all studies complied with Hardy-Weinberg equilibrium. By analyses of all studies, we found that the I/D genotype was a risk factor for increased susceptibility to vitiligo in Caucasians [odds ratio (OR) = 1.536, 95% confidence interval (CI) 1.096��2.152, P = 0.005], the D/D genotype increased the risk of vitiligo in Asians (Korean and Indians) (OR = 1.488, 95% CI 1.079��2.051, P = 0.015), while the I/I genotype decreased susceptibility to vitiligo in Indians and even in all Asians (Indians: OR = 0.569, 95% CI 0.342��0.948, P = 0.005; Asians: OR = 0.57, 95% CI 0.34��0.847, P = 0.005). Conclusion Our study suggests that ACE gene polymorphism is correlated with the vitiligo risk in Caucasians and Asians. Further large sample size research is needed to establish the exact association of ACE with pathogenesis of vitiligo.