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Deng Wei, Zhang Xiaoyan Peking University China?Japan Friendship School of Clinical Medicine, Beijing 100029, China ��Deng W��; Department of Dermatology and Venereology, China?Japan Friendship Hospital, Beijing 100029, China��Zhang XY�� Corresponding author: Zhang Xiaoyan, Email: superfawn@aliyun.com ��Abstract�� The immunologic processes of psoriasis and connective tissue diseases are very complex, which involve a large number of regulatory mechanisms. In recent years, scholars have found that Th17 cells play an important role in the pathogenesis of psoriasis, systemic lupus erythematosus ��SLE�� and other diseases, and their common cytokines include interleukin ��IL��?17, IL?21 and IL?23. Currently, the treatment of the two diseases usually includes glucocorticoids, immunosuppressive agents and biological agents targeting inflammatory pathways. In the treatment of coexisted psoriasis and connective tissue diseases, the use of glucocorticoids should be cautious. Treatment with immunosuppressive agents is only reported in some case reports, and lacks evidence from large sample?sized studies.

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