1. �㶫ҽ�ƴ�ѧ����ҽԺ
2. �㶫ҽѧԺ����ҽԺ
3. տ���㶫ҽѧԺ����ҽԺƤ����

��ժҪ�� �����Ը���T�ܰ�ϸ���ǽ��귢�ֵ�һ��CD4+Tϸ����Ⱥ�����ж�����ϸ������CD4+CD57+CXCR5+�����ϸ�����ӣ���ϸ������6��21��27����ת¼���ӣ�Bϸ���ܰ���6��ICOS�ͳ�������������1���������Ը���T�ܰ�ϸ������ϸ�����Ӳ�����Ϊ�����־����Ӱ������ķֻ������ܣ������������Լ�����أ���Bϸ����Ϳ������������Ҫ���ã����������Ը���T�ܰ�ϸ����ƽ��Դٽ��������ܺ���ֹ��������������Ҫ�������Ը���T�ܰ�ϸ���ĵ����漰ϸ��Ǩ�ơ��ֻ�������ȹ��̣�������������5��Bϸ���鳲�����������壬Bϸ���ܰ���6�����������Ը���T�ܰ�ϸ���ķֻ����죬ICOSȱʧ�����������Ը���T�ܰ�ϸ���Ĺ�����������������������1�źŵ�ȱʧ�ٽ������Ը���T�ܰ�ϸ���IJ������о���ʾ�������Ը���T�ܰ�ϸ�������ڲ���SLE�²���ά���������߲�������������ã�������SLE���߻���SLEģ���������Ը���T�ܰ�ϸ���������������࣬���뼲����չ�̶ȡ�������ˮƽ������ԡ������о�������SLE���߰�ϸ������21ˮƽ���ߣ����������Ը���T�ܰ�ϸ��ˮƽ��ء������Ը���T�ܰ�ϸ�����������ƻ���ֹSLE���鷢չ�İе�֮һ��

Yang Shanshan, Liu Shuang, Chen Rongyi, Shi Jianqiang Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, Guangdong, China Correspondence author: Shi Jianqiang, Email: jianqiangshi@126.com ��Abstract�� Follicular helper T lymphocytes ��Tfh cells��, one kind of recently identified CD4+ T cell subset with independent cell phenotype ��CD4+CD57+CXCR5+��, express cytokines including interleukin?6 ��IL?6��, IL?21 and IL?27, as well as transcription factors such as B?cell lymphoma 6 ��BCL6��, inducible costimulatory molecule��ICOS�� and programmed death?1 ��PD?1��. Cytokines expressed by Tfh cells not only serve as surface markers, but also affect differentiation and function of Tfh cells. Tfh cells are associated with autoimmune diseases, and play an important role in B cell activation and antibody production, so regulation of Tfh cell balance is crucial for promoting immune tolerance and preventing autoimmunity. The regulation of Tfh cells involves cell migration, differentiation, maturation and other processes. CXC chemokine receptor 5��CXCR5��is a B?cell?homing chemokine receptor, and BCL6 plays a dominant role in the differentiation and maturation of Tfh cells. ICOS absence leads to excessive growth of Tfh cells, and the absence of PD?1 signaling promotes the generation of Tfh cells. Studies have shown that Tfh cells may play an important role in the pathogenesis of systemic lupus erythematosus ��SLE�� and maintenance of autoimmune pathology. In both patients with and mouse models of SLE, the percentage of Tfh cells was significantly increased and correlated with disease progression and autoantibody levels. Recent studies have shown that elevated levels of IL?21 are associated with Tfh cell levels in the patients with SLE. In summary, Tfh cells may be an effective target for the treatment or prevention of SLE disease progression.

IL-36�¶�JAK/SATͨ·�ĵ�����SLE���²������о�