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Pan Qiaolin, Zhang Yi, Gao Fangming, Ye Xingdong Department of Dermatology, Institute of Dermatology, Guangzhou Medical University, Guangzhou Institute of Dermatology, Guangzhou 510095, China Corresponding author: Ye Xingdong, Email: yxingdong@qq.com ��Abstract�� Pemphigus is a chronic recurrent intraepidermal blistering skin disease caused by autoimmune response?induced epidermal acantholysis. It is characterized clinically by flaccid, thin?walled bullae arising on the erythematous skin, erosions and positive Nikolsky��s sign. According to clinical manifestations, pemphigus can be classified into pemphigus vulgaris��PV��, pemphigus vegetans��PVe��, pemphigus foliaceus��PF�� and pemphigus erythematous��PE��. The main pathogenesis of pemphigus is the presence of autoantibodies against keratinocyte desmogleins ��Dsgs�� in patients, but exact mechanisms leading to acantholysis are still unclear. With the development of proteomics, immunology, molecular biological techniques and further insights into the pathogenesis of pemphigus in the past decades, it has been shown that besides anti?Dsg auto antibodies, non?Dsg antibodies are also involved in the formation of acantholysis, which provids new potential therapeutic targets for pemphigus.