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Xu Lina, Fang Hong Department of Dermatology, The First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China Corresponding author: Fang Hong, Email: fanghongzy@sina.com ��Abstract�� Tight junctions ��TJs��, one of the main junctional structures between adjacent epithelial cells or endothelial cells, participate in the cell barrier function, material transportation and signal transduction, and maintenence of cellular polarity and physiological steady state. In recent years, more and more studies have found that TJs are closely associated with tumors arising from epithelial cells, such as skin tumors. Aberrant of tight junction?related proteins between keratinocytes and abnormal structure and function of TJs may both play key roles in the occurrence and development of skin tumors, suggesting that TJs play important roles in the diagnosis, differential diagnosis, treatment and prognosis of skin tumors.

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