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Zhu Yiqi, Tang Hui, Wang Duoqin, Shen Yanyun, Shao Yixin, Xu Jinhua Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China Corresponding author: Xu Jinhua, Email: hsyyxjh@163.com ��Abstract�� Various studies have demonstrated that the vitamin D level is significantly lower in patients with chronic urticaria than in healthy controls, and is negatively associated with the severity and duration of the disease. Although the causal relationship between vitamin D and chronic urticaria remains unclear, their potential relationship may be associated with immunoregulatory effects of vitamin D. Some researches indicate that vitamin D can regulate the function of immune cells, such as mast cells, lymphocytes and eosinophils, by influencing downstream signaling pathways and nuclear transcription level after binding to its receptor. Vitamin D is able to suppress the release of vasoactive mediators from mast cells, and affect the dynamic balance and migration of T?lymphocyte subsets, followed by the decline of interferon?�� ��IFN?�ã� level and increase of interleukin?10 ��IL?10�� level, which may be the important pathogenesis of chronic urticaria. Meanwhile, clinical trials reveal that vitamin D supplementation plays a potential supporting role in the treatment of chronic urticaria. Therefore, clear understanding of the causal relationship between vitamin D and occurrence of chronic urticaria, as well as the specific effect of vitamin D on main effector cells such as mast cells at cellular and genetic levels, will be helpful in finding new theoretical bases for the diagnosis and treatment of chronic urticaria.