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Geng Yi, Xu Xiulian Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China Corresponding author: Xu Xiulian, Email:xxlqjl@163.com ��Abstract�� Systemic sclerosis is usually considered to be the main cause of cutaneous sclerosis, but many other diseases can also manifest as cutaneous sclerosis and tissue fibrosis in clinic, which are easy to be confused with systemic sclerosis. This kind of diseases include a wide spectrum of heterogeneous diseases, ranging from a benign disease with a localized cutaneous involvement, to a widespread systemic, life?threatening disease. This review summarizes several main kinds of cutaneous fibrosing disorders, such as nephrogenic fibrosing dermopathy, scleromyxedema, POEMS syndrome, myeloma, Buschke scleroderma, eosinophilic fasciitis, eosinophilia?myalgia syndrome, carcinoid syndrome, porphyria cutanea tarda, chronic graft?versus host disease, environmentally triggered scleroderma?like disorders. Distinguishing the pathogenesis, clinical and pathological manifestations and therapeutic methods between this group of diseases will improve the understanding of these diseases, and has great clinical significance for their correct diagnosis and proper treatment.