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| PubMed | |
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Article by Yu,G.B |
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Article by Yang,y |
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Article by Chen,g |
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Article by Xu,X.L |
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Article by Gu,h |
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Article by Fang,p |
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Article by Xun,J.P |
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��ժҪ�� ަ����ѿ����һ��ԭ����Ƥ��Tϸ���ܰ������ٴ����ֶ��ֶ������������СRNA��miRNA����һ�ֳ�Լ22��������ķDZ���СRNA������ϸ���ֻ�����ֳ����л���������������miRNA�Ĺ���ʧ���������ķ��������á�Ŀǰ���֣�һЩmiRNA��ަ����ѿ�ķ�����������ϡ��ж�Ԥ�������ã�����ަ����ѿ�����ƾ���DZ�ڼ�ֵ����miR?155��miR?22��miR?150�ܴٽ�ަ����ѿ�ķ�����miR?233��miR?200c������ަ����ѿ�ס�һ��miRNA��miR?155��miR?203��miR?205�������ڼ������Ƥ��Tϸ���ܰ���������Ƥ������
Roles of microRNAs in mycosis fungoides
Wang Guangping, Yang Ying, Chen Hao, Xu Xiulian, Jia Hong, Fang Fang, Sun Jianfang Department of Pathology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China ��Wang GP, Yang Y, Chen H, Xu XL, Sun JF��; Department of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China ��Jia H��; Department of Dermatologic Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China ��Fang F�� Corresponding authors: Xu Xiulian, Email��xxlqjl@sina.com.cn; Sun Jianfang, Email: fangmin5758@aliyun.com ��Abstract�� Mycosis fungoides ��MF��,a kind of primary cutaneous T cell lymphoma ��CTCL�� with various manifestations, is easy to misdiagnose. MicroRNAs ��miRNAs�� are a group of small non?coding RNA molecules of about 22 nucleotides in length, and participate in many biological processes, such as cell differentiation, proliferation, metabolism and apoptosis. Dysfunction of miRNAs is involved in the development of neoplasms. Studies have shown that some miRNAs play important roles in the pathogenesis, auxiliary diagnosis and prediction of prognosis of MF, and have potential value in the treatment of MF. For example, miR?155, miR?22 and miR?150 can promote the development of MF, while miR?233 and miR?200c can inhibit it. A group of miRNAs, including miR?155, miR?203 and miR?205, are considered to be helpful in distinguishing CTCL from benign skin diseases.
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