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Xiong Xixi, Lu Yan. Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Corresponding author: Lu Yan, Email: luyan6289@163.com ��Abstract�� Cutaneous pseudolymphoma ��CPL�� refers to a group of lymphoproliferative diseases which are similar to cutaneous malignant lymphoma ��CML�� in terms of clinical manifestations and histopathological features, but does not meet the diagnostic criteria for CML. According to the main types of lymphocytes infiltrating the lesions, CPL is divided into cutaneous B?cell pseudolymphoma and cutaneous T?cell pseudolymphoma. CPL has various clinical manifestations, usually including red plaques, papules and nodules mostly in the head and neck. Some lesions appear to heal spontaneously and recur. Histologically, there may be infiltration of polyclonal proliferative lymphocytes, so it is easily mistaken for other malignant diseases. There are no specific treatments for CPL. Present therapeutic approaches include surgical excision, photodynamic therapy, interferon, etc, but recurrence may occur. Despite of a relatively good prognosis, CPL can progress to CML, so a long?term follow?up is indispensable.

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