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Hu Yingying, Yin Zhiqiang. Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Corresponding author: Yin Zhiqiang, Email: yzq2802@sina.com ��Abstract�� Interleukin?36 ��IL?36�� is mainly expressed in the skin, bronchial epithelium and brain tissues, and plays an important role in innate immunity and adaptive immunity by acting on epithelial cells and immune cells via binding to a heterodimer receptor comprised of IL?36 receptor ��IL?36R�� and IL?1 receptor accessory protein. IL?36 can induce the s of pro?inflammatory cytokines, antimicrobial peptides and chemokines to defend against pathogens in the environment. The release of pro?inflammatory cytokines and chemokines can also cause the occurrence of autoimmune diseases or immune?related inflammatory diseases, such as psoriasis. IL?36R, which is widely expressed at low levels and does not seem to be highly regulated, exerts immunological effects via binding to widely distributed IL?36. Therefore, anti?IL?36R antibodies are expected to be a potential therapy for psoriasis.

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