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| PubMed | |
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Article by Liu,q |
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Article by Jiang,n |
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Article by Zhang,M.T |
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Article by Zhu,H.L |
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Pathogenesis and treatment of actinic keratosis
Liu Qing*, Jiang Na, Zhang Erting, Zhu Huilan. *Guangzhou Medical University, Guangzhou 510000, China Corresponding author: Zhu Huilan, Email: zhlhuilan@126.com ��Abstract�� Actinic keratosis ��AK�� is a kind of superficial skin disease occurring at sun-exposed sites. The occurrence of AK is associated with long-term ultraviolet radiation-induced gene mutations, oxidative stress, inflammation, immunosuppression, impaired apoptosis, dysregulation of cell growth, proliferation and tissue remodeling. Currently, the treatment of AK mainly includes lesion-directed and field-directed therapies. Lesion-directed therapies include cryotherapy, ectomy and lasers, and field-directed therapies include externally applied agents such as fluorouracil, imiquimod, diclofenac, ingenol mebutate, tretinoin, and photodynamic therapy.
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