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Jiang Weiwei*, Zhu Yinghua, Jiao Yang, Yang Min. *Dalian Medical University, Dalian 116021, China Corresponding author: Zhu Yinghua, Email: zyh-office@163.com ��Abstract�� Bullous dermatoses are a class of skin diseases clinically characterized by blisters and erythema on the skin and mucous membrane. Both humoral and cellular immunity are involved in the pathogenesis of bullous dermatoses. In cellular immunity, initial T cells are activated under the effect of some cofactors after antigens specifically bind to receptors on these cells, then proliferate and differentiate into effector T cells. Subsequently, related cytokines on the surface of these effector T cells bind to relevent receptors on the surface of B cells to activate the B cells, followed by their differentiation into plasma cells and memory cells, which then produce high-affinity antibodies and induce immune responses. These adjuvant cytokines are mainly related to helper T cells and regulatory T cells. Researches on these cytokines are of great significance for determining the real origin of autoimmune bullous diseases and for developing targeted therapy of them.