1. ������Ƥ����ҽԺ
2. ������Ƥ����ҽԺ��м��ר��

��ժҪ�� ֬����֯������һ�ִ洢��ʣ��������֯��Ҳ��һ����Ծ���ڷ������٣��ɷ��ڶ�������������ʣ������غ�֬���صȣ���Щ���ʳ�Ϊ֬�����ӣ�������Ӫ��״̬�����ڷ���-����ϵͳ֮���໥���õ���Ҫ���ʡ�֬��ϸ���;���ϸ���������ͷŴ���֢���ӣ��������������ӡ���ϸ������6����ϸ������8������ϸ����������1��֬�����ӣ�֬���ء����ء��ֿ��صȣ������У�֬���ز�������ּ��ȵ��صֿ������й�ϵ�������п��׼�Ѫ�ܱ������á�������������α�Ͱ�ϸ������6������ϸ�����ӿ�����������֬���صIJ�������֬���ؿ������ƽ����γ�ϸ����T�ܰ�ϸ������������������α����ϸ������6��17��22�͸�����γ��֬����ˮƽ����м�������س̶ȼ�������������α�Ͱ�ϸ������6��ˮƽ�ʸ���ء�

1. Department of Dermatology, Dalianshipifubing Hospital
2.

Lu Hongyan, Song Shunpeng, Lyu Chengzhi. Department of Psoriasis, Dalian Dermatosis Hospital, Dalian 116021, China Corresponding author: Lyu Chengzhi, Email: dlpfb@126.com ��Abstract�� Adipose tissue not only can store excess energy, but also serves as an active endocrine organ secreting a variety of bioactive substances, such as leptin and adiponectin. These substances are called adipokines, and are important mediators of the interaction between host nutritional status and the neuroendocrine-immune system. Adipocytes and macrophages both participate in the release of proinflammatory cytokines, such as tumor necrosis factor ��TNF��, interleukin-6 ��IL-6��, IL-8, monocyte chemotactic protein-1 ��MCP-1�� and adipokines ��including adiponectin, leptin, resistin, and so on��. Adiponectin is not only closely associated with obesity and insulin resistance, but also has anti?-inflammatory and vascular protective effects. Some cytokines such as TNF-α and IL?-6 can inhibit the of adiponectin in vitro, while adiponectin can suppress the secretion of TNF-α, IL-6, IL-17, IL-22 and interferon γ by keratinocytes and T lymphocytes. The level of adiponectin is negatively correlated with the severity of psoriasis as well as levels of TNF-α and IL-6.