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��ժҪ�� Rosai-Dorfman����һ���ټ����ۼ��ܰͽ��Ƥ��������֢����֯ϸ������֢����֯�����Դ������ʷḻ����֯ϸ�������������˶��������黯ȾɫCD68��S100����Ϊ�������ò�����Դ�������в������Ŀǰ��Ϊ������ܵĻ����Ǿ���ϸ������̼������յ��ֻ����������Ծ���ϸ�����ܰ�ϸ��������Լ�����ϸ�����ӣ�����������?��B��������������α����ϸ������1β����ϸ������6������ϸ��������������������ӡ�ͬʱ���������Ⱦ������������SLC29A3����ͻ����ܲ��뷢����Rosai-Dorfman���IJ���ͨ�������ԣ�������㷺�����ϵͳ֢״��һ���������г����ڷ���Ƥ�ʼ��ء����ƻ��ƽ������ơ�

Luo Yingjun, Ma Han. Department of Dermatology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China Corresponding author: Ma Han, Email: drmahan@sina.com ��Abstract�� Rosai-Dorfman disease is a rare benign inflammatory cutaneous histiocytosis with the involvement of lymph nodes. It is histopathologically characterized by proliferation and emperipolesis of histiocytes with abundant cytoplasm that stain positive for CD68 and S-100. The origin and pathogenesis of Rosai-Dorfman disease are unclear at present, and the most probable pathogeneses are that macrophage colony-stimulating factor induces the differentiation of immunosuppressive macrophages, hampers the activation of lymphocytes, and increases the s of multiple cytokines, including nuclear factor kappa B, tumor necrosis factor-alpha, interleukin-1β ��IL-1β��, IL-6 and various chemokine receptors. In addition, human herpes virus infection, malignant tumors and mutations in the SLC29A3 gene may contribute to the occurrence of Rosai-Dorfman disease. It usually undergoes spontaneous regression. Surgical excision, oral glucocorticoids, radiotherapy and chemotherapy are often used when lesions are extensive or systemic symptoms appear.