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Zhang Qinghua, Li Nan, Chen Rongyi, Shi Jianqiang. Guangdong Medical University�� Zhanjiang 524023, Guangdong, China Corresponding author: Shi Jianqiang, Email: jianqiangshi@126.com ��Abstract�� Under the effect of different cytokines, naive T cells can differentiate into multiple cell subsets, including Th1, Th2, Th17, Treg cells, and so on. These T cell subsets and their cytokines play important roles in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus ��SLE��. Interleukin-36 (IL-36), including IL-36α, IL-36β and IL-36γ, shows stronger immunoregulatory and immunoactivation effects than traditional IL-1 family members, and participates in the pathophysiological process of autoimmune diseases by activating the mitogen-activated protein kinase and nuclear factor kappa-B. To investigate the effect of IL-36 on differentiation of T cells may facilitate the clarification of SLE pathogenesis, and provide new ideas to its treatment.

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