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Liu Aiying, Zi Shaoxia, Jin Wangyang. Department of Dermatovenereology, China Meitan General Hospital, Beijing 100028, China Corresponding author: Liu Aiying, Email: laydlr@163.com ��Abstract�� With further insights into action mechanisms of botulinum toxin type A, it has been applied more and more widely in dermatology. Botulinum toxin type A can be used to treat axillary and palmar hyperhidrosis by acting on the vegetative nervous system, treat postherpetic neuralgia through its analgesic effect, treat keloid and scar by inhibiting fibroblast proliferation and collagen synthesis, and to delay deepening of wrinkles by transient skeletal muscle paralysis. The most disadvantage of botulinum toxin type A injection is that it can only result in temporary relief or disappearance of symptoms, and repeated injections are required for their long-term control. A lot of reports have indicated that the effects of botulinum toxin type A injection can be maintained for 12 months at most.