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��ժҪ�� Ŀ�� ̽����м������Ƥ��CD69+ Tϸ���ı�Ｐ���뼲����ԵĹ�ϵ������ �����黯���31����м������Ƥ��ͷ�Ƥ����CD69+ Tϸ����Ƥ���еı���6�������˽��ж��ա� ��� CD69+ Tϸ����Ҫ�ֲ���Ƥ����Ƥ��31����м������Ƥ��ͷ�Ƥ�����Ƥ�У�CD69+ Tϸ���ֱ�Ϊ��35.16±12.67��%�ͣ�8.70±3.29��%��Ƥ�����Ը��ڷ�Ƥ��t = 12.5��P < 0.01����6�������˶���Ƥ����CD69+ Tϸ����8.71±2.55��%�����Ե�����м��Ƥ��t = 5.03��P < 0.01�������Ƥ����ȣ�������ͳ��ѧ���壨t = 0.05��P > 0.05����20����������11���ȶ�����м������Ƥ����CD69+ Tϸ���ֱ�Ϊ��40.89±10.31��%�ͣ�24.46±9.49��%�����������Ը����ȶ��ڣ�t = 0.36��P < 0.01�������� ��м������Ƥ����CD69+ Tϸ��������ߣ��뼲���Ļ���йء�

Hao Zhimin*, Xiang Zhi, Luan Chao, Yang Yonghong, Hu Yu, Chen Hao, Chen Min, Wang Baoxi. *Department of Dermatology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing 210042, China Corresponding authors: Chen Min, Email: drchenmin@126.com; Wang Baoxi, Email: wangbx@ncstdlc.org ��Abstract�� Objective To measure the of CD69+ T lymphocytes in skin lesions of patients with psoriasis, and to explore its relationship with disease activity. Methods Lesional and non-lesional skin samples were collected from 31 patients with psoriasis, and normal skin samples obtained from 6 healthy individuals served as controls. Immunohistochemical staining was performed to measure the of CD69+ T lymphocytes in these skin samples. Results CD69+ T lymphocytes were mainly distributed in the dermis. The percentage of CD69+ T lymphocytes was significantly higher in lesional skin than in non-lesional skin ��35.16% ± 12.67% vs. 8.70% ± 3.29%, t = 12.5, P < 0.01��, higher in lesional skin from 20 patients with acute psoriasis than in that from 11 patients with stable psoriasis ��40.89% ± 10.31% vs. 24.46% ± 9.49%, t = 0.36, P < 0.01��, but significantly lower in normal control skin than in lesional skin ��8.71% ± 2.55% vs. 35.16% ± 12.67%, t = 5.03, P < 0.01��, and insignificantly different between normal control skin and non-lesional skin ��t = 0.05, P > 0.05��. Conclusion The of CD69+ T lymphocytes is markedly increased in psoriatic lesions, which may be associated with disease activity.

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