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Wang Dan, Yang Shengbo, Huang Jinhua. Department of Dermatology, Third Xiangya Hospital, Central South University, Changsha 410013, China Corresponding author: Jinhua Huang, Email: huangjinhua60@126.com ��Abstract�� DNA hydroxymethylation refers to a chemical modification process in which 5-methylcytosine ��5mC�� is converted to 5-hydroxymethylcytosine ��5hmC�� by the ten-eleven translocation ��TET�� protein family. This conversion is an important intermediate step in active DNA demethylation, which can influence gene expressions by dynamically regulating DNA methylation levels. DNA hydroxymethylation can be modulated by TET proteins, the Krebs cycle-related enzymes, vitamin C, miRNAs, etc. Like patients with hematological malignancies or other solid cancers, those with cutaneous malignant melanoma have been reported to have decreased 5-hydroxymethylcytosine levels and abnormal DNA hydroxymethylation, hinting that DNA hydroxymethylation is related to the occurrence, development and prognosis of cutaneous malignant melanoma.