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ang Jia, Li Liming, Long Jia, Xu Cui, Yang Xueyuan, Jiang Mingjun. Central Laboratory, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China Corresponding authors: Yang Xueyuan, Email: yangxueyuan@medmail.com.cn; Jiang Mingjun, Email: drmingjunjiang@163.com ��Abstract�� MicroRNAs ��miRNAs��, as an important regulatory factor in development of multiple malignant tumors, take part in cell proliferation, differentiation and apoptosis. Studies have found aberrant expressions of various miRNAs in melanoma. Among these miRNAs, the Let-7 family, miRNA-137, miRNA-200c and miRNA-196a act as tumor suppressor genes, while miRNA-221/222, miRNA-30b/30d, miRNA-146a, miRNA-214 and miRNA-182 act as oncogenes. Studies on melanoma-related miRNAs will enrich knowledge about molecular pathogenesis of melanoma, and provide new ideas for early diagnosis and treatment of melanoma.