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Wang Xiaopo, Sun Jianfang. Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China Corresponding author: Sun Jianfang, Email: fangmin5758@aliyun.com ��Abstract�� Epigenetics means heritable changes in gene expressions without alterations in DNA sequence, and mainly involves DNA methylation, histone modification and non-coding RNA regulation. Cutaneous T-cell lymphoma is a class of malignant T-cell lymphoproliferative diseases originated from the skin. Mycosis fungoides and Sezary syndrome are the most common cutaneous T-cell lymphoma. Recent studies have shown that epigenetics not only plays an important role in the occurrence and development of cutaneous T-cell lymphoma, but also provides insights into the treatment of cutaneous T-cell lymphoma.