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Long Jia, Xu Cui, Yang Jia, Li Liming, Jiang Mingjun. Central Laboratory, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China Corresponding author: Jiang Mingjun, Email: Drmingjunjiang@163.com ��Abstract�� DNA methylation is an important epigenetic event leading to heritable changes in gene expression without alterations in DNA sequence. With the development of techniques for detection of DNA methylation, more and more studies have indicated that aberrant DNA methylation is associated with various nonmalignant tumors. In addition, it has been demonstrated or implied that aberrant DNA methylation is closely related to the pathogenesis of many inflammatory skin diseases, such as psoriasis, systemic lupus erythematosus, atopic dermatitis, systemic scleroderma, androgenetic alopecia, chronic eczema, pemphigus, etc. However, it is unclear how aberrant DNA methylation patterns play their biological roles in these diseases. Further in-depth studies will provide new clues for investigations into related diseases.