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��ժҪ�� IgG4����Լ����ǽ����������һ���²��֣��������ۼ������κ���֯�����١�IgG4����Լ�������������Ϊ Ѫ��IgG4ˮƽ�����Լ��������ٺ���֯��IgG4���Խ�ϸ�����󡣽��������֣�IgG4����Լ�������Ƥ���ı䣬Ƥ��ɱ���Ϊ����Ƥ������֢״������Mikulicz����Ƥ����ϸ������֢�������ܰ�����Ѫ���ܰ�������������ϸ�������ľ�岡�ȡ�IgG4����Լ������߶�ϵͳ��Ƥ�ʼ������Ʒ�Ӧ�Ϻá�

Zhang Xueying*, Qiao Jianjun. *Department of Dermatology, Shanxian Center Hospital, Heze 274300, Shandong, China Corresponding author: Zhang Xueying, Email: xueying-shanxian@163.com ��Abstract�� Immunoglobulin G4 ��IgG4��-related disease is a recently proposed entity, and can affect any tissue or organ in the human body. It is characterized by increased serum levels of IgG4 and infiltration of abundant IgG4-positive cells in various organs and tissues. Recent studies have found that IgG4-related disease may present with various skin manifestations, such as Mikulicz′s disease, cutaneous plasmacytosis, pseudo-lymphoma, angiolymphoid hyperplasia with eosinophilia and Kimura′s disease. Systemic glucocorticoids are effective for the treatment of IgG4-related disease.plasmacytosis, pseudolymphoma, angiolymphoid hyperplasia with eosinophilia and Kimura′s disease. Systemic glucocorticoids are effective for the treatment of IgG4-related disease.