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Cui Xiaomei, Zhu Jing, Chen Xiaodong. Department of Dermatology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu, China Corresponding author: Chen Xiaodong, Email: dermatochen@163.com ��Abstract�� Pathological scars are caused by abnormal healing after skin damage, and are characterized by fibroblast proliferation and collagen deposition. At clinics, comprehensive therapy is usually applied for treating scars, and has exerted some therapeutic effects. However, the severe adverse effects of some therapies have caused treatment refusal by patients. Photodynamic therapy has been widely used to treat superficial lesions, and has also been well studied for therapeutic intervention in visceral tumors. Because of the hypotoxicity of photodynamic therapy, its therapeutic effect on scars has been widely studied by domestic and foreign scholars. These researches have shown that photodynamic therapy can inhibit the proliferation and migration of fibroblasts, induce apoptosis, inhibit the formation of extracellular matrix, improve the appearance of scars, and exert definite therapeutic effects on scars.