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Hao Junfeng, Jin Liang, Wang Gang. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi′an 710032, China Corresponding author: Wang Gang, Email: xjwgang@fmmu.edu.cn ��Abstract�� Keratinocytes not only form physical barriers, but also have important immunologic functions. They can express antigen presentation-related molecules ��such as major histocompatibility complex class �� ��MHC-�� and intercellular adhesion molecule-1�� with changes of MHC-��levels, in some disorders or after stimulation by cytokines such as interferon-γ. In addition, some studies have indicated that activated keratinocytes can process and present endogenous or exogenous antigens to activate antigen-specific T-lymphocytes. This function of keratinocytes is of great significance in elucidating the pathogenesis of related skin diseases and developing specific targeted therapy. Compared with classical antigen-presenting cells, the antigen-presenting function of keratinocytes is somewhat limited.