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Ning Weixuan*, Wang Suiquan, Xu Ai′e. *Department of Dermatology, Guangxing Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310007, China Corresponding author: Xu Ai′e, Email: xuaiehz@msn.com ��Abstract�� The Janus protein tyrosine kinases ��Jaks��, a kind of nonreceptor tyrosine kinases, participate in the signal transduction of many cytokines and growth factors, play an important role in the differentiation of multiple cells, and are associated with various inflammatory and immune-mediated dermatoses as well as skin neoplasms. The changes of Jak activity can lead to overactivation or inactivation of signaling pathways, both of which can cause diseases. Jaks are also an important target for drug development. Abnormal activation of different Jaks exists in different dermatoses. Many Jak inhibitors have shown favorable therapeutic effects on multiple dermatoses.