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Zhang Sufang*, Zhou Pingyu. *Shanghai Skin Disease Clinical College, Anhui Medical University, Shanghai 200050, China Corresponding author: Zhou Pingyu, Email: zpyls@yahoo.com ��Abstract�� Syphilis, a chronic sexually transmitted disease caused by Treponema pallidum ��Tp��, can affect multiple organs. At present, Tp can not been cultured in vitro for a long time and is difficult to obtain, which has hampered the exploration into the pathogenesis of syphilis, optimization of syphilis diagnosis and treatment, and development of syphilis vaccines. The identification of complete genome sequence of Tp, successful expressions of some important membrane proteins such as TprK, Tp0483 and Tp0155, and in?۲depth study of the structural characteristics, antigenicity and immunoprotective effect of these membrane proteins have provided the basis for and possibility of investigating into the pathogenesis of, optimizing the diagnosis and treatment of, and developing vaccines for, syphilis. The authors summarize recent advances in some major membrane proteins of Tp with diagnostic value and immunoprotective effect.

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