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Bai Juan, Qiao Jianjun, Fang Hong. Department of Dermatology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Corresponding author: Fang Hong, Email: fanghongzy@sina.com ��Abstract�� Human papillomavirus ��HPV�� can cause a variety of diseases, such as verruca vulgaris, verruca plana, condyloma acuminatum, bowenoid papulosis, cervical cancer, and so on. Moreover, HPV can efficiently escape from the recognization by innate immune system, which may be attributed to epithelial tropism, non-lytic replication, and low expression of capsid protein with high immunogenicity in the basal lamina of immunoactive stratified squamous epithelium. The carcinogenicity of HPV and high incidence of HPV-related diseases have received extensive attention. The innate immunity against HPV infection has become a research hotspot. In this review, the authors summarize multiple dermal immune cells involved in the innate immunity against HPV, including keratinocytes, dendritic cells, Langerhans cells, plasmacytoid dendritic cells, natural killer cells and invariant natural killer T cells. ��Key words�� Human papillomavirus; Immunology; Escape reaction; Keratinocytes; Dendritic cells; Langerhans cells; Toll-like receptors

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