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Zhao Sha, Zhu Xiaofang. Department of Dermatology, Clinical Medical College of Yangzhou University, Yangzhou 225001, China Corresponding author: Zhu Xiaofang, Email: sharonzhu66@126.com ��Abstract�� Toll-like receptors ��TLRs��, a group of pattern recognition receptors, participate in both innate and adaptive immunity by recognizing pathogen-associated molecular patterns. There are more than 10 kinds of members in the TLR family. TLR7, one member of this family, is located on endolysosomal membranes, mainly recognizes single-stranded nucleic acids and plays an important role in recognization and transmission of viral infections. Recent studies have revealed that TLR7 plays an important role in some skin diseases. On the one hand, TLR7 can induce and aggravate vitiligo, lupus erythematosus and psoriasis; on the other hand, it can stimulate antifungal immune responses in the host, promote the conversion to Th1-type immune response in atopic dermatitis, and serve as an adjuvant treatment for skin neoplasms and condyloma acuminatum through its specific agonist imiquimod.