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Chen Mincong, Wang Jianqin*. *Department of Dermatology, Guangzhou First People′s Hospital, Guangzhou 510180, China Corresponding author: Wang Jianqin, Email: jianqinwang@tom.com ��Abstract�� Caspase 8 is closely associated with death receptor-mediated apoptosis. In recent years, some progress has been made in studies on the roles of caspase 8 in apoptosis. Besides initiating apoptosis, caspase 8 has many other biological functions, such as participating in T cell proliferation and immune responses, cell adhesion/migration, vascular endothelium formation, etc. As a key initiator of the Fas-mediated apoptotic pathway, caspase 8 is closely associated with repair of skin damage, cicatrization and lichen planus, and also plays some roles in counteracting inflammation. ��Key words�� Skin diseases; Caspase 8; Apoptosis