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Li Xiao, Gu Guixiong, Li Wei. Affiliated Children′s Hospital of Soochow University, Suzhou 215003, China Corresponding authors: Gu Guixiong, Email: szggx000@163.com; Li Wei, Email: carfield1981@126.com ��Abstract�� MicroRNAs ��miRNAs�� are a group of small non-coding single-stranded RNAs of 20 �� 22 nucleotides ��nt�� in length, and can regulate gene expressions at post-transcriptional level. miRNA-146a, a member of the miRNA family, participates in various biological processes such as cellular proliferation, immunity, inflammation, neoplasms, etc. Researches have revealed that miRNA-146a is associated with multiple dermatoses, such as melanoma, psoriasis, systemic lupus erythematosus and skin photoaging. In this review, the authors summarize latest progress in biosynthesis and action mechanisms of miRNA-146a as well as its roles in relevant diseases.

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