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Zhang Liangyu, Chen Yang, Wang Xiang. Department of Dermatology, 98th Hospital of People′s Liberation Army, Anhui Medical University, Huzhou 313000, Zhejiang, China Corresponding author: Chen Yang, Email: 98cy@163.com ��Abstract�� Psoriasis is a chronic inflammatory and immunologic disease of unknown etiology. It has been found that increased number of dendritic cells ��DCs�� and effector T-lymphocytes infiltrate skin lesions of psoriasis, indicating that DCs are involved in the inflammatory response in psoriasis. In normal skin, there are mainly three kinds of DCs: epidermal Langerhans cells, dermal myeloid DCs and plasmacytoid DCs. In skin lesions of psoriasis, the three kinds of DCs interact with T cells, keratinocytes and neutrophilic granulocytes, which can induce and aggravate inflammatory responses. In addition, type I interferon secreted by plasmacytoid DCs in a Toll-like receptor-dependent manner can enhance the activation of myeloid DCs and release of inflammatory mediators.

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