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Chen Wenjuan, Shi Yuling. Department of Dermatology, Shanghai Tenth People′s Hospital of Tongji University, Shanghai 200072, China Corresponding aurthor: Shi Yuling, Email: shiyuling1973@gmail.com ��Abstract�� Psoriasis is a chronic inflammatory dermatosis caused by multiple factors in vivo and in vitro, such as genes, environment, psychiatric and psychological factors, etc. Various immunocytes, especially all subsets of CD4+ helper T cells, with their cytokines form complex regulatory networks, such as the interleukin ��IL��-23/T helper type 17 ��Th17�� axis and IL-4/Th2 axis, to regulate the initiation and progression of psoriasis. The innate immunity mediated by antigen-presenting cells ��APC�� and natural killer cells and acquired immunity mediated by T cells constitute the basis for maintaining immune homeostasis. This review summarizes recent advances in psoriasis-related innate and acquired immunocytes and associated signaling pathways, which may help to further clarify the immunological pathogenesis of psoriasis.

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