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Yuan Chunyu, Ju Mei, Chen Kun. Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China Corresponding authors: Ju Mei, Email: Jumeiweng@163.com; Chen Kun, Email: kunchen181@aliyun.com ��Abstract�� Condyloma acuminatum ��CA�� is a sexually transmitted disease caused by human papillomavirus ��HPV��. In recent years, reports on childhood CA have increased. Childhood CA is transmitted via various routes and the possibility of sexual abuse cannot be ignored. Meanwhile, HPV type and clinical manifestations are different between childhood and adult CA. The treatment of childhood CA includes physical therapy, surgery, topical medications, and so on. Safety, efficacy and tolerability should be fully considered in selection of treatment protocols. For CA in children under 12 years of age, there are no treatments approved by the United States Food and Drug Administration.