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Xu Bin, Zhang Ruzhi. Department of Dermatology, Third Affiliated Hospital of Soochow University, Changzhou 213001, Jiangsu, China Corresponding author: Zhang Ruzhi, Email: zhangruzhi628@163.com ��Abstract�� Induced pluripotent stem cells��iPSCs�� have all the characteristics of embryonic stem cells��ESCs��, including pluripotency and the potential to differentiate into various somatic cells. The iPSCs originating from skin not only can be easily obtained, but also are more liable to directly differentiate into functional skin cells such as keratinocytes, melanocytes and fibroblasts. Autologous iPSCs have been considered as an ideal cell bank for cell therapy, because they have a sufficient source, and allow the avoidance of related ethical issues and immunologic rejection. Revertant mosaicism can be used in combination with iPSC technology to obtain sufficient functional patient-specific revertant cells for genodermatosis, which allows the avoidance of immunologic rejection and insertional mutagenesis observed in traditional gene therapy.

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