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Ma Pingping, Guo Hongwei, Shi Jianqiang. Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, Guangdong, China Corresponding author: Guo Hongwei, Email: ghwroot@hotmail.com ��Abstract�� Alopecia areata is a complex immune-mediated disease that targets anagen hair follicles. Treatment strategies are determined mainly according to patients′ age, as well as the extent and duration of scalp involvement. Various therapeutic regimens have been described for alopecia areata, including corticosteroids, minoxidil, immunotherapy, biological agents, etc, but none of them is curative or preventive. Moreover, many of these therapeutic agents have not been subjected to randomized, controlled trials. The conquest of alopecia areata is still challenging. Now alopecia areata is considered to be an autoimmune disease with the loss of immune privilege in hair follicles. It is an ideal strategy to control alopecia areata through initial immunosuppression followed by reconstruction of the immune system.

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