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Yu Xiaoling, Jin Hongzhong. Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China Corresponding author: Jin Hongzhong, Email: jinhongzhong@263.net ��Abstract�� Psoriasis vulgaris ��PsV�� and psoriatic arthritis ��PsA�� are two clinical types of psoriasis with distinct clinical manifestations. The difference in clinical presentations between the two types may be associated with genetic, immunological and environmental factors. HLA-B, MICA*00801 homozygote, CARD15, tumor necrosis factor ��TNF��*-857T, TRAF3IP2 and interleukin ��IL��-13 genes are more frequent, while HLA-Cw*06, MICA*016 and LCE genes are less frequent, in PsA patients than in PsV patients. CD8+ T cells, TNF-α and IL-22 play important roles in joint damage in PsA patients, while CD4+ T cells and vascular growth factors are associated with psoriatic skin lesions. Infection, injury and manual labor have a close relationship with the initiation of PsA, while smoking and drinking seem to be negatively associated with the occurrence of PsA.

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