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��ժҪ�� Ŀ�� ����������ؼ����������ԭ������IgE ��sIgE�������Լ���ʼ����ٴ�������ԡ����� ������Ӧ��Ƥ�ס�ʪ�ݡ����ȹ�����Ƥ�������ߣ�Ӧ������ӡ�������sIgE�������Ƶ����ʾ��������sIgE���ٴ�֢״������ԡ���� ��2 178�������ߣ���Ӧ��Ƥ��163����ʪ��268����ݡ����1 522���������Ա���61��������������22����������142�����ļ�������з�����������Ӧ��Ƥ�׻���sIgE ≥ 2���� ≥ 3���������ʷֱ�Ϊ54.60%��38.04%����������ʪ�35.07%��20.15%����ݡ���36.47%��19.05%����P �� 0.001������Ӧ��Ƥ�׹���ԭsIgE3���� ≥ 4��ʱ�뻼���ٴ�֢״������Խϸߣ�61.11%��83.05%������������ʪ�9.61%��14.63%����ݡ���7.36%��15.43%����������ͳ��ѧ���壨P �� 0.001������Ӧ��Ƥ�׻��߳����Ĺ���ԭΪ������15.95%�������11.04%����èë��7.36%�������壨6.14%�����ݳ���5.52%�������� ����ԭsIgE�������Ӧ��Ƥ�׵��ٴ�Ӧ�ü�ֵ����ʪ���ݡ���

Li Hui, Feng Haixia, Yu Xianshui��Wang Lu��Liu Yufeng��Li Wei. Xijing Hospital��Fourth Military Medical University, Xi′an 710032, China Corresponding author: Li Wei, Email��liwei1@fmmu.edu.cn ��Abstract�� Objective To detect allergen-specific IgE ��sIgE��antibodies in patients with allergic diseases and to assess their clinical relevance. Methods Serum samples were collected from 2 036 outpatients with allergic diseases ��including 163 cases of atopic dermatitis, 268 eczema, 1 522 urticaria, 61 allergic rhinitis, 22 allergic asthma�� as well as 142 healthy human controls. Immunoblotting was performed to detect sIgE antibodies in these samples. A survey was conducted with a self-designed questionnaire to assess clinical reactivity to tested allergens in these subjects. Results The proportions of patients with a sIgE score of grade ≥ 2 and those with a sIgE score of grade ≥ 3 were 54.60% and 38.04% in patients with atopic dermatitis, respectively, significantly higher than those in patients with eczema ��35.07% and 20.15%��respectively, both P < 0.001��and patients with urticaria��36.47% and 19.05%��respectively, both P < 0.001��. The coincidence rate between sIgE detection results and self-reported allergy was 61.11% and 83.05% in atopic dermatitis patients with a sIgE score of grade 3 and grade ≥ 4, respectively , significantly higher than that in eczema patients��9.61% and 14.63%��respectively, both P < 0.001�� and urticaria patients ��7.36% and 15.43%��respectively, both P < 0.001��. The five most common allergens were dust mite ��15.95%��, Artemisia argyi��11.04%��, cat hair ��7.36%��, egg white ��6.14%�� and house dust ��5.52%��among patients with atopic dermatitis. Conclusion sIgE detection appears to be of higher clinical value to patients with atopic dermatitis than to those with eczema or urticaria.